Despite their widespread use in the management of chronic obstructive pulmonary disease (COPD), pharmacological treatments often demonstrate limited efficacy in alleviating symptoms such as dyspnea and psychological pressure. These limitations highlight the need for complementary nonpharmacological interventions. This study aimed to evaluate the efficacy of traditional Chinese exercise (TCE) in improving lung function and mental health among patients with COPD.

We conducted a comprehensive search across several databases: CNKI (1979-2024), Wanfang (1998-2024), PubMed (1966-2024), the Cochrane Library (1999-2024), and Web of Science (1961-2024), up to September 2024, to gather all randomized controlled trials (RCTs) studies that evaluated the effects of TCE as the primary intervention for patients with COPD. The results were analyzed and presented using Review Manager 5.4 software, ensuring a systematic approach to data interpretation and visualization.

67 studies were included and encompassing 5,475 patients. The meta-analysis demonstrated that TCE significantly improved various outcomes in COPD patients, including FEV1 [MD = 0.28, 95% CI (0.23, 0.33), p < 0.001], FEV1% [MD = 5.53, 95% CI (4.41, 6.65), p < 0.001], FVC [MD = 0.31, 95% CI (0.29, 0.34), p < 0.001], FEV1/FVC (%) [MD = 6.00, 95% CI (4.27, 7.73), p < 0.001], the 6MWT [MD = 42.14, 95% CI (36.54, 47.73), p < 0.001], CAT [MD = -4.20, 95% CI (-4.74, -3.66), p < 0.001], anxiety [MD = -1.26, 95% CI (-1.64, -0.89), p < 0.001], and depression [MD = -1.26, 95% CI (-1.59, -0.94), p < 0.001].

TCE significantly improved lung function and alleviated anxiety and depression in COPD patients. This study not only highlights the value of TCE as a nonpharmacological intervention but also offers new directions for psychological management, warranting broader implementation.

CRD42024586079, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024586079.

Mental health issues among children and adolescents have increased, especially after the COVID-19 pandemic. Despite awareness, less than half get needed care, leading to long-term consequences. The World Health Organization calls for integrated, preventive community interventions. In this paper, we present The Mental Health Clinical Liaison Programme for Schools in the Community of Madrid, Spain, which features school-based activities delivered by multidisciplinary mental health teams, offering early detection, intervention, and prevention strategies for children and adolescents. We describe the activities implemented, present the evidence supporting them, provide preliminary data, and discuss the scope and challenges of the programme. In 2023-2024, the programme intervened in 53 primary and secondary schools, helping identify in 876 cases, evaluating 356, and referring 122 to other services. It supported interventions for 179 patients already in mental healthcare and 34 reintegrations after psychiatric hospitalization. Anti-stigma workshops have been conducted, involving approximately 1620 students. Ongoing research aims to evaluate the effectiveness and cost-effectiveness of these interventions to ensure continuous improvement in mental health services for young people.

This narrative review provides an overview of the structure, financing models, and challenges facing the German mental healthcare system for adults. The German mental healthcare system is divided into distinct sectors, including inpatient, outpatient, rehabilitation, and regional complementary services, each with its own financing mechanisms. Statutory health insurance, covering about 88% of the population, funds the majority of the system. Germany allocates 13% of its GDP to healthcare-one of the highest proportions globally-with over 10% of this directed toward mental health. Key challenges include an overemphasis on inpatient services, poor coordination between inpatient and outpatient sectors, insufficient severity-based treatment allocation, limited adherence to clinical guidelines, and a lack of digitalization and routine outcome evaluations. The COVID-19 pandemic led to a temporary reduction in service use and intensified issues with inter-sector collaboration. In the long-term, a healthcare workforce shortage further complicates care delivery. Proposed solutions include regional budgets for integrated care, outcome-based quality assurance, stepped-care models to optimize treatment allocation, and digital infrastructure improvements for better data sharing and transparency. These reforms aim to enhance patient-centered care, improve outcomes, and make more efficient use of resources.

Respiratory disorders, , continue to pose a major global health burden. Their complexity and heterogeneity challenge accurate diagnosis, effective monitoring, and therapeutic decision-making. Exhaled breath condensate (EBC) provides a reliable, non-invasive means of sampling the molecular environment of the airways.

This review presents the state-of-the-art in EBC-based omics approaches-particularly metabolomics and proteomics-to characterize molecular signatures associated with chronic respiratory (e.g. asthma, chronic obstructive pulmonary disease, and rhinitis) and infectious diseases (e.g. COVID-19).

We critically examine findings from studies applying nuclear magnetic resonance (NMR), mass spectrometry (MS), and sensor-based technologies to analyze EBC across various respiratory conditions. NMR, valued for its reproducibility and minimal sample preparation, consistently discriminates among disease phenotypes, identifies distinct metabotypes, and monitors treatment response over time. MS-based approaches afford enhanced sensitivity and specificity, enabling detailed profiling of inflammatory mediators, such as lipid-derived eicosanoids and amino acid derivatives. Proteomic studies reveal protein-level alterations associated with inflammation and tissue remodeling. In COVID-19 and long COVID, metabolomic and volatile compound profiling distinguishes affected individuals from healthy controls suggesting clinical potential. However, inconsistent sample processing and lack of analytical standardization remain limiting factors.

EBC profiling shows clear promise for improving diagnosis, monitoring, and stratification in respiratory medicine. Yet, translation into clinical practice is hindered by limited standardization and validation. Broader, longitudinal studies will be essential to establish robust molecular signatures across disease states. This review underscores the timely need to implement breathomics investigations to gain mechanistic insight into the underlying biology of respiratory diseases.

There is growing concern about the mental health of students in higher education institutions (HEIs) across the United Kingdom. Increasingly diverse student populations, the legacy of the COVID-19 pandemic, and variations in policies and service provision across the 4 UK nations have highlighted the need for a comprehensive understanding of student mental health. Current literature remains fragmented, with limited synthesis comparing national contexts. This protocol outlines a scoping review to systematically map the evidence base, identify key research gaps, and inform future research priorities and interventions.

The primary aim is to identify and map existing research on student mental health in UK HEIs. Specific objectives include exploring how student mental health is defined and measured, identifying risk factors, assessing support systems and interventions, and highlighting gaps in research across England, Scotland, Wales, and Northern Ireland.

This scoping review will follow Joanna Briggs Institute methodology and be reported in line with PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guidelines. Studies will be eligible for inclusion if they (1) were conducted in the United Kingdom; (2) involved students aged 16 years and older enrolled in HEIs; (3) addressed mental health-related outcomes, definitions, or interventions; and (4) were published in English from 2005 onwards. Excluded materials include gray literature not identified during database searching. A comprehensive 3-step search strategy will be used. Initially, APA PsycInfo and MEDLINE (Ovid) will be searched, followed by a broader search across Scopus, Web of Science (Core Collection), Child and Adolescent Development Studies, and the Cochrane Library. Reference lists of the included studies will be screened for additional sources. All citations will be managed using Covidence, and study selection will involve title/abstract screening and full-text review by independent reviewers. Data extraction will include information on study design, population characteristics, mental health outcomes, measures used, interventions, and key findings. Data will be presented in tabular and narrative forms and, where appropriate, descriptive content analysis will be used.

As of April 2025, preliminary searches and pilot screenings have been completed. The full database search and data charting phase will commence in June 2025. The final synthesis, analysis, and stakeholder consultation are scheduled between September and November 2025. The full review will be completed by December 2025, with dissemination activities planned through early 2026.

This review will provide a comprehensive overview of student mental health research within UK HEIs. It will highlight the key national differences, emerging themes, and underresearched areas, supporting more targeted, evidence-informed policy and practice. Limitations include language and gray literature exclusions. Nonetheless, the findings are expected to make a timely and meaningful contribution to research and intervention strategies in UK higher education.

PRR1-10.2196/65594.

Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare vasculitis characterized by increased eosinophils in human tissues and peripheral blood. In this case, we present a 53-year-old female patient with EGPA. By this case and literature review, we want to explain the early manifestations, diagnosis, and management of EGPA, which will help clinicians to understand the disease and attach importance to the possibility of dupilumab-induced EGPA, to improve the early diagnosis rate of EGPA, and reduce misdiagnosis and missed diagnosis.

The diagnostic criteria for EGPA established by the American Rheumatology Association (ACR) in 2022 were used; these criteria encompass clinical presentation, laboratory tests, and pathological biopsy. In addition, we conducted a comprehensive literature review on this case.

We present a 53-year-old female patient who developed severe peripheral neuropathic pain after the administration of dupilumab for the treatment of refractory asthma and sinusitis. The patient's symptoms, laboratory examination findings, and nasopharyngeal biopsy pathology results collectively support the diagnosis of EGPA. When dupilumab was converted to mepolizumab combined with glucocorticoid, her peripheral neuropathic pain and asthma symptoms were dramatically relieved. Our literature review also provides a detailed discussion on the relationship between Dupilumab and EGPA.

We present a case of EGPA with peripheral neuropathic pain induced by Dupilumab, and mepolizumab has a good therapeutic effect on this patient. Our literature review shows that although dupilumab is effective in treating eosinophilic airway inflammatory diseases, clinicians must pay attention to the possibility of dupilumab inducing or aggravating EGPAs.

A post-hepatectomy patient with acute liver injury, renal failure and hypercarbic respiratory failure who received ropivacaine rectus sheath catheter analgesia developed altered mental status, perioral numbness, hypotension and new conduction abnormalities highly suspicious for local anaesthetic systemic toxicity. Although this patient initially responded to intravenous lipid emulsion therapy with resolution of his perioral numbness and hypotension, his multisystem critical illness progressed, which makes establishing a time course of clear diagnoses and therapeutic responses complex. It is possible, given the temporal association, that the high-dose lipid therapy contributed to his rapid development of acute respiratory distress syndrome, acute pancreatitis, laboratory interference and dialysis circuit obstructions.

The lung microbiota is integral to maintaining microenvironmental homeostasis, influencing immune regulation, host defense against pathogens, and overall respiratory health. The dynamic interplay among the lung microbiota emphasizes their significance in shaping the respiratory milieu and potential impact on diverse pulmonary affections. This investigation aimed to identify the effects of invasive mechanical ventilation on the lung microbiome. Materials and Methods: A systematic review was conducted with registration number CRD42023461618, based on a search of PubMed, SCOPUS, and Web of Science databases, in line with the PRISMA guidelines. To achieve this, "(mechanical ventilation) AND (microbiota)" was used as the search term, replicable across all databases. The closing date of the search was 12 March 2025, and the evidence was scored using the MINORS scale. Results: A total of 16 studies were included, with patients aged 13.6 months to 76 years, predominantly male (64.2%). Common ICU admission diagnoses requiring invasive mechanical ventilation (IMV) included pneumonia, acute respiratory failure, and COVID-19. IMV was associated with reduced lung microbiota diversity and an increased prevalence of pathogenic bacteria, including Prevotella, Streptococcus, Staphylococcus, Pseudomonas, and Acinetobacter. The most frequently used antibiotics were cephalosporins, aminoglycosides, and penicillins. IMV-induced pulmonary dysbiosis correlated with higher infection risk and mortality, particularly in pneumonia and COVID-19 cases. Factors such as antimicrobial therapy, enteral nutrition, and systemic inflammation contributed to these alterations. Conclusions: Invasive mechanical ventilation has been associated with the development of alterations in the respiratory microbiome, resulting in reduced diversity of lung microorganisms.

In this study, we aim to report the persistent presence of anti-SARS-CoV-2 immunoglobulins in pre-immunized mare offspring. Three mares from Vital Brazil Institute were pre-immunized with recombinant SARS-CoV-2 spike protein and became pregnant during this period. After parturition, the mares' serum and colostrum/milk and foal serum were collected over 6 weeks. Our results have shown high and persistent presence of IgG and neutralizing antibodies over the weeks not only in the mares' serum, as expected, but in mares' colostrum/milk and foal serum as well-what were very surprising. This peculiar approach, which we were able to track specifically antibodies produced from an antigen inoculated only in the pregnant mares', is distinct from the usual methodology applied in the current reports in this field. Thus, together, these data and our methodology could lead to new approaches to better understanding about equine passive immunization by newborn's breast-feeding.

There has been an unusual increase in the incidence of anti-glomerular basement membrane disease, anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis, and double-positive cases since the coronavirus disease 2019 (COVID-19) pandemic. Rare cases have been consistently reported, including anti-glomerular basement membrane antibody and ANCA double-positive crescentic glomerulonephritis after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as well as coexistent membranous nephropathy and proteinase 3 ANCA-associated crescentic glomerulonephritis following vaccination. We described both anti-phospholipase A2 receptor (PLA2R) antibody-positive and -negative membranous nephropathy superimposed on anti-glomerular basement membrane disease. Upon and beyond these findings, we herein reported three cases of biopsy-confirmed membranous nephropathy concurrent with anti-glomerular basement membrane antibody and ANCA double-negative crescentic formation, which manifested as acute kidney injury clinically. In one case, repeated renal biopsies confirmed de novo occurrence of crescents in the setting of PLA2R-associated primary membranous nephropathy immediately after SARS-CoV-2 infection. Subsequent use of anti-CD20 agents led to substantial recovery of renal function in two patients. Our report indicated that an indirect process resulting from downstream implications of this viral infection may be responsible for a plethora of unusual entities in glomerular diseases since the COVID-19 pandemic. As such, emerging insights may help decipher the complexity of these increasingly recognized yet equally detrimental clinicopathologic combinations, particularly in the post-COVID-19 era.