Successful treatment with rituximab of a type 2 diabetes patient with antibody-mediated insulin resistance syndrome: A case report.
Insulin antibody-mediated insulin resistance is a rare autoimmune mechanism that can cause severe hyperglycemia.
A 52-year-old male patient was admitted to our hospital with complaints of polydipsia, polyuria, and weight loss (8 kg in 6 months). He was diagnosed with type 2 diabetes mellitus at age 33.
Type 2 diabetes mellitus with antibody-mediated insulin resistance syndrome.
Rituximab infusion in a 500 mg dose was given 2 times in a 2-week interval.
A significant response was achieved 1 month later with fasting plasma glucose: 120 mg/dL (6.7 mmol/L), glycosylated hemoglobin A1c: 7.6% (59.6 mmol/mol), and anti-insulin antibodies: 0.001 U/mL. Clinically improved response persisted for about 6 months.
Clinicians should be aware of the antibody-mediated insulin resistance, recognize suggestive signs and symptoms, pursue appropriate diagnostic evaluation, and treatment approach.
A 52-year-old male patient was admitted to our hospital with complaints of polydipsia, polyuria, and weight loss (8 kg in 6 months). He was diagnosed with type 2 diabetes mellitus at age 33.
Type 2 diabetes mellitus with antibody-mediated insulin resistance syndrome.
Rituximab infusion in a 500 mg dose was given 2 times in a 2-week interval.
A significant response was achieved 1 month later with fasting plasma glucose: 120 mg/dL (6.7 mmol/L), glycosylated hemoglobin A1c: 7.6% (59.6 mmol/mol), and anti-insulin antibodies: 0.001 U/mL. Clinically improved response persisted for about 6 months.
Clinicians should be aware of the antibody-mediated insulin resistance, recognize suggestive signs and symptoms, pursue appropriate diagnostic evaluation, and treatment approach.
Authors
Çakmak Çakmak, Tekin Tekin, Hacişahinoğullari Hacişahinoğullari, Mutlu Mutlu, Çaklili Çaklili, Nasibopva Nasibopva, Ok Ok, Saribeyliler Saribeyliler, Araz Araz, Yalin Yalin, Selçukbiricik Selçukbiricik, Gül Gül, Üzüm Üzüm, Karşidağ Karşidağ, Dinççağ Dinççağ, Yilmaz Yilmaz, Satman Satman
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