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The development and progression of diabetes mellitus and its complications are closely related to glycotoxicity and inflammatory interactions. Glycotoxicity triggered by hyperglycemia damages vascular endothelial cells through mechanisms such as oxidative stress and the accumulation of advanced glycation end-products(AGEs), leading to microcirculatory dysfunction and the pathological state of "glycoconjugate stasis in collaterals". Meanwhile, the persistent presence of chronic inflammation further exacerbates glycotoxic injury to tissues, forming a vicious cycle that promotes the occurrence and development of diabetic complications. According to traditional Chinese medicine(TCM) theory, "glycoconjugate stasis in collaterals" is highly correlated with pathological factors such as phlegm-dampness, blood stasis, and heat-toxicity. The core pathogenesis lies in the dysfunction of Qi movement and the mutual entanglement of phlegm and blood stasis, with the deficiency of healthy Qi as the internal root. TCM intervention strategies focus on clearing glycotoxicity to eliminate the source of disease, resolving stasis to dredge the vessels and collaterals, regulating Qi and blood to balance Yin and Yang, strengthening the spleen to eliminate dampness and turbidity, and protecting internal organs to prevent disease transmission. These approaches aim to disrupt the vicious cycle of glycotoxicity and inflammation, improve the state of "glycoconjugate stasis in collaterals", and delay or reverse the progression of diabetes and its complications. This paper explores the pathogenesis and treatment of diabetes mellitus and its complications in "glycoconjugate stasis in collaterals" from the perspective of glycotoxicity-inflammation interactions, providing new ideas and methods for clinical intervention. Through comprehensive, multi-target and multi-pathway interventions, TCM can not only improve metabolic disorders and microcirculatory dysfunction but also effectively alleviate inflammatory responses, offering a unique theoretical foundation and practical guidance for the prevention and treatment of diabetes mellitus and its complications.