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Nasopharyngeal carcinomas (NPC) are malignancies that have seen growing burdens with human papilloma virus (HPV) infection. This investigation aims to characterize social determinant factor of health (SDoH) differences across HPV-differentiated NPC across the USA. NPC-patients with confirmed-HPV status between 2010 and 2018 from the Surveillance-Epidemiology-End Results (SEER) database were analyzed by cox-proportional and logistic regressions of age, sex, race-ethnicity, census-level rurality-urbanicity, and census-level Yost-Socioeconomic Status (SES)-Index measures to assess mortality, staging, and delayed-treatment differences. Among 820-HPV( -) and 402-HPV(+) NPCs, both NPC-cohorts displayed reduced overall mortality risk with younger age (HR 0.56, 95% CI 0.38-0.81; HR 0.57, 0.45-0.73) and higher risk with male sex (HR 1.71, 95% CI 1.11-2.64; HR 1.42, 95% CI 1.07-1.87). For HPV(-) only, Hispanic (HR 0.51, 95% CI 0.32-0.82) and Asian ethnicities (HR 0.44, 95% CI 0.33-0.58) reduced overall mortality risk, while low Yost-SES-Index increased it (HR 1.44, 1.14-1.87). For HPV( -) only, delayed treatment occurred with lower Yost-SES-Index (OR 1.97, 95% CI 1.16-3.42). Using the Yost-SES-Index and other individual/census-level SDoH, multilevel SDoH-analyses of HPV-differentiated NPC-patients display vast prognostic and treatment differences based on HPV-status. These present specific targets to prospectively and strategically address drivers of disparity with limited public health resources.