Epigenetic Regulation and Targeted Therapy in Gall Bladder Cancer.
Gall bladder cancer is a formidable malignancy known for its aggressive nature and often late-stage diagnosis. In recent years, oncology has changed basic assumptions towards personalized and targeted therapies. Significant emphasis has been paid to research and clinical contexts about DNA methylation, histone changes, and microRNA alterations as key epigenetic pathways linked to the development of gall bladder cancer. The review delves into the potential of epigenetic markers as diagnostic and prognostic tools and discusses their utility in finding novel therapeutic targets. Targeted therapies have demonstrated effectiveness in addressing various types of cancer, and gall bladder cancer is no exception. The recent advancements in targeted therapies tailored for gall bladder cancer have been elaborated, underscoring the vital role of precision medicine in customizing treatment plans to suit individual patients. The review also examines the challenges and opportunities associated with the development of therapies specifically designed to target epigenetic changes, potentially offering treatment options that are both more efficacious and less toxic.