Dissecting human cortical similarity networks across the lifespan.
The human cortex exhibits remarkable morphometric similarity between regions; however, the form and extent of lifespan network remodeling remain unknown. Here, we show the spatiotemporal maturation of morphometric brain networks, using multimodal neuroimaging data from 33,937 healthy participants aged 0-80 years. Global architecture matures from birth to early adulthood through enhanced modularity and small worldness. Early development features cytoarchitecturally distinct remodeling: sensory cortices exhibit increased morphometric differentiation, paralimbic cortices show increased morphometric similarity, and association cortices retain stable hub roles. Morphology-function coupling peaks in early adolescence and then decreases, supporting protracted functional maturation. These growth patterns of morphometric networks are correlated with gene expression related to synaptic signaling, neurodevelopment, and metabolism. Normative models based on morphometric networks identify person-specific, connectivity-phenotypic deviations in 1,202 patients with brain disorders. These data provide a blueprint for elucidating the principle of cortical network reconfiguration and a benchmark for quantifying interindividual network variations.
Authors
Liang Liang, Sun Sun, Xia Xia, Zhao Zhao, Gong Gong, Li Li, Liao Liao, Cui Cui, Duan Duan, Pang Pang, Wang Wang, Yu Yu, Bi Bi, Chen Chen, Chen Chen, Chen Chen, Chen Chen, Cheng Cheng, Cheng Cheng, Dai Dai, Deng Deng, Ding Ding, Dong Dong, Gao Gao, Gong Gong, Han Han, Han Han, Huang Huang, Huang Huang, Huo Huo, Li Li, Lin Lin, Lin Lin, Liu Liu, Liu Liu, Liu Liu, Liu Liu, Liu Liu, Lu Lu, Ma Ma, Men Men, Qin Qin, Qin Qin, Qiu Qiu, Qiu Qiu, Si Si, Tan Tan, Tang Tang, Tao Tao, Wang Wang, Wang Wang, Wang Wang, Wang Wang, Wang Wang, Wang Wang, Wang Wang, Wei Wei, Wu Wu, Xie Xie, Xu Xu, Xu Xu, Xu Xu, Yang Yang, Yu Yu, Yuan Yuan, Zeng Zeng, Zhang Zhang, Zhang Zhang, Zhao Zhao, Zheng Zheng, Zhong Zhong, , , He He
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