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This case report discusses a female patient diagnosed with moderately differentiated squamous cell carcinoma (SCC) in the maxillofacial region. She presented with a persistent ulcer on the hard palate that had lasted for 1.5 years. The tumour showed extensive local and regional spread, affecting critical structures such as the orbit, infratemporal fossa and temporal lobe, along with significant bone destruction. Investigations revealed pulmonary involvement and mediastinal lymphadenopathy, making the tumour inoperable according to National Comprehensive Cancer Network guidelines due to the involvement of essential structures. Neoadjuvant chemotherapy was recommended for this patient. This case underscores the aggressive nature of advanced maxillofacial SCC and emphasises the need for early detection, timely evidence-based treatment and a multidisciplinary approach to enhance patient outcomes.