Association of hepatic steatosis index with asymptomatic intracranial arterial stenosis: a cross-sectional study.
The hepatic steatosis index (HSI) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD), a condition that can increase the risk of atherosclerosis. However, limited data are available on the association between HSI and asymptomatic intracranial arterial stenosis (aICAS).
This cross-sectional study aimed to investigate the association between HSI and aICAS among Chinese rural residents. The study enrolled 1788 participants aged ≥ 40 years without a history of clinical stroke or transient ischemic attack from the Rose Asymptomatic Intracranial Artery Stenosis (RICAS) cohort. We defined aICAS as ≥ 50% stenosis in intracranial arteries confirmed through combined transcranial Doppler (TCD) ultrasound and magnetic resonance angiography (MRA). The HSI was calculated based on gender, diabetes, body mass index (BMI), and transaminases level. The multivariate logistic regression models were deployed to explore the association of HSI with aICAS.
Of the 1788 participants, the participants with aICAS comparing with those without aICAS had a significantly higher HSI. Controlling for confounding factors, HSI ≥ 36 was significantly associated with aICAS (OR = 3.08; 95%CI: 1.46-6.49, P = 0.003), especially multiple aICAS (OR = 4.21; 95%CI: 1.31-13.47, P = 0.016). The prevalence of aICAS increased with the value of HSI (P for trend = 0.001). Subgroup analysis further showed the association between HSI and aICAS risk only in non-abdominally obese populations (P for interaction = 0.023).
HSI may serve as a practical non-invasive biomarker for aICAS risk stratification, thus facilitating early detection in community settings, particularly in non-abdominally obese populations.
This cross-sectional study aimed to investigate the association between HSI and aICAS among Chinese rural residents. The study enrolled 1788 participants aged ≥ 40 years without a history of clinical stroke or transient ischemic attack from the Rose Asymptomatic Intracranial Artery Stenosis (RICAS) cohort. We defined aICAS as ≥ 50% stenosis in intracranial arteries confirmed through combined transcranial Doppler (TCD) ultrasound and magnetic resonance angiography (MRA). The HSI was calculated based on gender, diabetes, body mass index (BMI), and transaminases level. The multivariate logistic regression models were deployed to explore the association of HSI with aICAS.
Of the 1788 participants, the participants with aICAS comparing with those without aICAS had a significantly higher HSI. Controlling for confounding factors, HSI ≥ 36 was significantly associated with aICAS (OR = 3.08; 95%CI: 1.46-6.49, P = 0.003), especially multiple aICAS (OR = 4.21; 95%CI: 1.31-13.47, P = 0.016). The prevalence of aICAS increased with the value of HSI (P for trend = 0.001). Subgroup analysis further showed the association between HSI and aICAS risk only in non-abdominally obese populations (P for interaction = 0.023).
HSI may serve as a practical non-invasive biomarker for aICAS risk stratification, thus facilitating early detection in community settings, particularly in non-abdominally obese populations.
Authors
Han Han, Pan Pan, Li Li, Liu Liu, Jin Jin, Zhao Zhao, Ma Ma, Wang Wang, Yan Yan, Sun Sun
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