A bibliometric analysis of 2000-2024 on interventional therapy for liver cancer and tumor immune microenvironment.

In recent years, the tumor immune microenvironment (TIME) has been gradually emphasized in liver cancer interventional therapy. The present study aimed to evaluate the current research hotspots and developmental trends of TIME from the perspective of bibliometrics.

Publications related to interventional therapy, liver cancer, and TIME were searched on the Web of Science (WOS) Core Collection database for the years 2000-2024, and bibliometric analyses were performed using VOSviewer, CiteSpace, and R "Bibliometrix".

A bibliometric analysis was conducted on the TIME in liver cancer interventional therapy using data from 2000-2024. The study included 277 articles from 21 regions/countries, with China and the USA leading. The number of articles is increasing annually. Fudan University and Huazhong University of Science and Technology are major research institutions. The Journal of Hepatocellular Carcinoma is the most popular journal, while Hepatology is the most cited. Zheng Chuansheng published the most papers, and Llovet was the most co-cited. Research topics include the mechanism of the TIME in interventional therapy and novel therapies. Emerging hotspots are "Immunotargeted inhibition", "tumor microenvironment", and "immunotherapy".

This is the first comprehensive bibliometric study in this field, providing insights into research trends and new directions.
Cancer
Care/Management

Authors

Liang Liang, Li Li, Xu Xu, Luo Luo, You You, Yuan Yuan, Zhou Zhou, Yi Yi, Tu Tu, Xu Xu
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